The video shows the chaos that erupted on the pitch following the final whistle as players chased and taunted each while fans also followed suit around the ground in South America.
Uruguay’s Interior Ministry said: “It started on the field, and it seemed incongruous that the players asked the fans not to fight when the fights had already started on the field.”
He added that a firearm was taken from at least one police officer while six police vehicles were also damaged.
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Palmeiras boss Eduardo Baptista accused the home side of deliberately preventing his players from leaving the field, sparking the mass fighting.
The Brazilian champions had come from two down at half time to claim victory and almost guarantee their spot in the knockout phases of South America’s version of the Champions League.
Melo had previously accused some of the Penarol players of using racist abuse towards him when the sides met in Sao Paulo and he later warned he would not back down from slapping them when they met again.
Following the melee on Wednesday, he said: “It’s lamentable. Premeditated the way it was it could have been much worse.
“When we tried to leave the field the tunnel was closed and security guards stopped us from leaving. Our own security got us off the field and stopped something worse happening. ”
CONMEBOL did not make any immediate comment on the violent clashes.
Palmeiras currently top their group after collecting 10 points from four matches. Penarol are bottom after picking up just three.